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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53a473fea37261825e9fc511117f5d01645f26dc9d9b4dc42be1e803b4dda733' 
  AND token = 'nrUGpr4MGrXsxO/kIdSNlbckEq3li6qiMRDRM/TqiYQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}