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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f5dc4c656f8cfde5f66f489de72ad14679587956bb295c1d481115e780b468' 
  AND token = '1r0SDDUldkCZ40hYsPEauCNVBj27gIyN2w+zKZ7C1Q4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}