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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53b158049df4fe30b1d5abb76c6ca542d164c14e18bb9b8e3a809d3fad3da2ab' 
  AND token = 'qgSwWmPtMVEJF1qdoBgPFQqJxYP2PkWiH71+gfbVmPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}