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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '51a236137aa792717d816e791e1daa206e6400e26f91ed3486e9c27b185b29e1' 
  AND token = 'AAAQUIcYaxPZRv+v+YcfPkPm6g39uKQKpyjgOsInqbY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}