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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21608490a0b083984ae40bfb9b5b0d227bc987202b8aea17c6ef01b018c12402' 
  AND token = '9/TrYMHWxx5tH8feuKrZcmRGsUAIxdTflsM3HWTeDN8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}