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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12bfc0f89b76e4e32ca766552d574360ad424a37ab4f3f7727a15e2a4dc2e50d' 
  AND token = 'Ve+de0TQLr8HPzeeMoPsTjNePdSQ5xvXfnBS33+uz/E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}