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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e003842629136983c6028020b398e3007467df829d645b81ad735f5503b56fb' 
  AND token = 'zmFdmFlEubj3Sh9NJr2O959nje9vVyOw/taBeod1sdI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}