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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e279051f10be4886ee7ff7e161d412ceceebe4bce5bfa760d325925cef21e89' 
  AND token = 'ffEmlCBxhFRucIfmgOaC+HTAhyKNPBQezIZXgCQ9k8M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}