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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4a4d78b156a48d824bfb35736372c8e289e3b57071db2663963f418cb95ccc8' 
  AND token = 'tTioPf5fSpObWZOigkQFvtHdiL3tPVqg9X83otmABIo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}