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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72a18e619aa777f1e6bcce58465a9f6f77d4e68599e292e59e33d7fd38121a39' 
  AND token = 'tTd0xXy/QuhR48tr31VDvkbjYiBcBWTQzMF6Uom3LHM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}