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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e1611fee66ed3e0241b6a4b0ebf475bb40e0d0788e945508c62e5aac6a3d45d' 
  AND token = 'TDA2o6nE/UrVjsFZX+ZF7NRKLhmd0clI9vWhrdFojws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}