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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48e6628b1abecc1b697c4f15ea652e54019c38709476552ccb58158a9439309c' 
  AND token = 'xv5I/MLcpIzjxbs39Yn+PZbvhA4FiM4+Ig64Xz4nAxc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}