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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2def146caec4d859966a6c8b0020fe4f02e215cd0b35f3fa9106e9ae846755ff' 
  AND token = '2D0vuM1M3PclsW53A7ulTvEwPSYfE7CyP9D+mZ0UuLo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}