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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fc100e30ff7a1d65fbe53fd5dbedff22d89689b8219f663de7650dee631a9458' 
  AND token = 'YMXGbz+5+QnDeG0H9gSAyn7O1v0nMe2sbBSfO0UmTM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}