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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e5494c43d00b3b05a0c82376fd3ef2091e3bdf2a740373d3b8e729f58e3bc8' 
  AND token = 'GUjO/NArnj9r4tC4DwWYWRUSt+MAhDwz8WWQOsChNRE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}