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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '504900d3a6145b4e6138601ed37a69cb1414ab193a7d1ca911849d34248f187b' 
  AND token = 'EYx0v6+pONe44/IQepbQubCP0TVL5fk8lXf/fJnl2Gw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}