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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d5cb714e57728a004fbf6f1145a43fbe4fede26d953f6b860b2b1469b5570f5' 
  AND token = 'IqDB0RF1YEZtPIGh2Bh75kGRuw5bCSS4Sj5UztlKXTQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}