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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'def724131527b8a1d39fafe88a813a1b8ddefff3bbd80c7973f5b58090f7dbd8' 
  AND token = 'bOXLvO/CeO2T21QMyd1asU+mahSVRa/rFRgETF7aq9Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}