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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '620330b49867abeeef5ecdf8f2866a1d7b729e50f60b2f0919f23734e024a75d' 
  AND token = '28OKImKkBcgnGmFEtElXdLV03sdVpag95dGXLz3tloI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}