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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f80c429b1394c8de5dfe84012a38f0fe0dc307d492dab9f6a3567b9b538fd13' 
  AND token = 'ontS2abhaKBl0DgrezcOa33zsPjlBUZYScD3VR3vxX4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}