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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '949adde1b1944665f798f60e9d5b4b8eb9f8679a106d1f98d958436381f04d9e' 
  AND token = 'oeUL8sg9+jkUhRt0Gpdma9I8JtKPcuzPmf4jdpghi1Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}