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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '380c507e70a5246acbf0467b537043a80bdd3958ac737cf3fa30974510c9e1e4' 
  AND token = '5biFQp171Zz7MhVRrlAHWMdtf39VjNBaqCvccRSuxsc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}