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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1600ca7f12bfdb894736768079f02681df9101289a60e4fc5121e0d75d5afaa5' 
  AND token = 'zVTyxCOwzqezbuq0WnxEwOa8RVLYZFXjdFLsh8IPmQE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}