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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14b5223b54c4f79dc5c52af38eeeacf490a99aadd05ec46f7f9a737a90305897' 
  AND token = 'DFeR/7z58viM4MswBDFHzJzQJUwyWTkvwRkL9fywZAA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}