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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd80eaaa5d222d20d8643d484415e526673c6399fb0633b447cc842b7444e7d2a' 
  AND token = '+YNaMjjbHGCcPNNPBQdB8EmTF/DBx1E/JUZB/XsWya8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}