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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0fa0812d146677d24f78f60601e75f9a068d8e6106030ef6919a2137af36fbfd' 
  AND token = 'vMIOS9eC65+KS/TQwVAIk49oSk2d1PETVBjvpXcoK7s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}