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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b78060d4009790af35fd8ce05fe51b6e7b6b3a34359d77f80c2a726daf24794d' 
  AND token = 'zSoZYr96DLfugUlh4qrlLS40lFm7K6KeQ4AnE+pp92k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}