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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c497e7386474603a1943ddd4f3de80e316f17fd9fcccd80476d27ddcaf2710c' 
  AND token = 'rd8Eh6/B2zJHsWtAkHciHA2RIpbulgKN5BQ6Zq7JQH4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}