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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50cd2446847747d6ce4201ce46d16ee35221f4fe3e920ed9ee4f1a0fd01302eb' 
  AND token = 'JZlqPA52toQQWT9OF8EEdxcKepqx5LqAq/PZ16oY0vg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}