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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e0e20c32dc38cffc8199d68f8b4854fea8abe4d2e3a684cb9f3668f256fa729' 
  AND token = 'PKNy3lFxyS0VHXcFN3czUbcl2VC/egaB3ECD66Psomw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}