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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '456f4fceadce93d2c7d176860ffa068a5fa4f3fc845af001e154f65b6601a1c2' 
  AND token = 'FQqAgWIMhdoIi8Hav+eAnxeysr1GqO+1oL1AAwQFKmc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}