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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c70336f5bfbe15b03d7b5e7b997fe6bd44ab541c45719fc4dd42a53144e0746' 
  AND token = 'CLbU+e6ZYDBbWRbcG9vPbi/1vICT65PVrrqq3DpHl8Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}