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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ffe264877d8e46909f12ab095c8e37d68d4901be5acc4c5919d640591c76910' 
  AND token = 'Jt6NqP1VFBw8n5I3sJ3TFh3emDZei8lLDTSYEkXTfFM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}