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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b0aa38d1846fb12282315f295118a296a4a0139b560941b72270dd21164d0f4' 
  AND token = 'kkYSMsBgCg+ROm73YImnB6ofwnCFnPe1dxDBudXN0us=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}