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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8fa0aea02f9b5ceb1936ce3d21f298c7d5c2b3fc4989357b32882f1cbacc559' 
  AND token = '10Gwd2ukg5Cd2Br+dza2oDn7/9IxtcRqo0vRrlrA1EE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}