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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd2fd346311db1561aead5cc241b606c1cea65cb768d33ef5a417a1fed221f721' 
  AND token = 'imwPZrVAbUm4QSE2PBT8UEU/sQt+kB64vYts1UUZMdc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}