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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8c2a329e1772726878a3a83d3c79e25e073a1542a865d7c2163c526d3397e9b' 
  AND token = '+amYM2V+kxka9pQ7cwbtiFvySebr6oSCBMGEJeTsqPo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}