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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4289a8d3cac7df19ed63f361f31b1ac7f29a16d47fafe51b40577467971c21aa' 
  AND token = 'TM5pwzyd5AlUrsbygHDF3Fo/1BRPk2Xhm7tQkcbWGJA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}