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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50b4814633b533685b7c988fbc31742e08fb9a121bb81a3d5285191f427c9593' 
  AND token = '9OiEkL2X5+xmLA9hEUBAOO6JC8kvIVqqbeLUZtGJsGo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}