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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52393912ea22ef7cf3c5edfe4a73fa080d55ad68a861a8520a4e08f8967bb122' 
  AND token = 'ikxdB4Eo4Xs7RIWEOCmYiDBpWRYyueCxMaac3zIxU8A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}