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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '822ac615b214308a0a4df2bf16449fec994a8b6bb82eaf0453b984391cf78b05' 
  AND token = 'EnX38+cLjrequrzTqsB6q5mklY19QI8FmKSzzvfGUUU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}