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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ce8760020a4feb0d380989402a319b3d94f38741e3955fca62f6397d65acde3' 
  AND token = 'tm/EtNqaED4kZ7ixONUrRRtzHeEFfN8ZcNt90GD2H+c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}