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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5dc04de86de9f8284cdbdbb51b21615206ce10e7af0b9b9508dd9eda86a7e2d' 
  AND token = 'DuBIaKpoRxqAtz05mFX+h8yN4yx4BQHKLOgyu3g2pUo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}