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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c6222f3dad6971c603bc69aa42c0ff06d9f13fa35549a2eef859ac926a2b91a8' 
  AND token = 'hpe7TVMsROIoCqeWIVwhjPlkfNumCAdzjFbTytr7jZI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}