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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222a4179c338fc6bc562e86f61d11cbf1af0653542ab91e3aead9d09fcb01276' 
  AND token = 'ROoq31oUlh7j8HpQgx3hskhOdrlUJGDdZ3n7TXO5lSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}