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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05a5cf69089247aa9398cef62666c514f4e3a01081acb51804dbea5e580c46dc' 
  AND token = 'O0Gse7U7ihGx7FzSb9L7wMXPrMU4QHj1JntI/C2aiPA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}