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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '225ae4244ce6577bb04c4138a21749ea7fde16e34ce9005df0f9151b4164c732' 
  AND token = 'a2vqlSpImWZ+G/uVlquu0KDt6Aov3RwnNvs6vaRCgEQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}