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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'def678ac798eeafebab753ceec415802d0b196c1565c5eee07a734c0c36f0855' 
  AND token = 'qI/Ih4t7uO0tsTRoSE49RpysnGO+s46Hdmy5IUY8VHE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}