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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729877c74b9bc1d5cd3901080cbc745884ea38c40745f38a91730ff67be1208b' 
  AND token = 'u5RKs/xxd6Ox+z+wkGW6a1mjfWKZ/2j0VYx+xcW9reU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}