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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a0c1d7d1ae17d58f1bdc72963349cabb63011780c5870f6fa70d2b8e7a56d260' 
  AND token = 'VBSUspka018QpoucfWi+P2KjQbbS6w7UtWC58xi/eyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}